Oxidative Stress in Stem Cell Aging
نویسندگان
چکیده
منابع مشابه
Oxidative Stress in Stem Cell Aging
Stem cell aging is a process in which stem cells progressively lose their ability to self-renew or differentiate, succumb to senescence or apoptosis, and eventually become functionally depleted. Unresolved oxidative stress and concomitant oxidative damages of cellular macromolecules including nucleic acids, proteins, lipids, and carbohydrates have been recognized to contribute to stem cell agin...
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-----------------------------------------------------------------------------------------------3 Introduction--------------------------------------------------------------------------------------------4 Main text: Reactive oxygen species ----------------------------------------------------------------------4 Antioxidant defenses-------------------------------------------------------------------...
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The production of reactive species is an inevitable by-product of metabolism and thus, life itself. Since reactive species are able to damage cellular structures, especially proteins, as the most abundant macromolecule of mammalian cells, systems are necessary which regulate and preserve a functional cellular protein pool, in a process termed "proteostasis". Not only the mammalian protein pool ...
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ژورنال
عنوان ژورنال: Cell Transplantation
سال: 2017
ISSN: 0963-6897,1555-3892
DOI: 10.1177/0963689717735407